Beilstein Handbuch Methamphetamine

Beilstein is a real chemical reference.  Sweden hasn’t been a paragon of honesty lately.  Norwegia more like got what would have kept Sweden honester, 83 dead, and a pile of winter snow on them.  I’m perplexed about God missing about 75 Swedes instead.  Anyway, I see what I want from some damn Sweden person.

N.N,-Dibenzyliden-iitJrytendi.-in-*ii ElUyfa$”esiumbromid in Ather und anschliessend.

mit einer

“rn*orrilkal.

wss. fto”tg

“91

Niqumphosphat und wenig Ammonium’

cUoria @an Alphen, Robert’ R’ 54 [1935] 361′ 364)’

KPgo: 139o’ . A. o :-r r:^ i* r^raan’lan Artilzel erha.ltene Ver-

Beim Erhitzen unter 2b Torr auf 210o ist die im folgenden Artikel erhaltene veI

bindung

See that?  That’s the original German, where all the science is.  Now let’s place that within “trasnslate”.  Minute…

NN, dibenzylidene iitJrytendi.-in * ii ElUyfa $ “esiumbromid in ether and then.
with a
“rn * orrilkal.
wss. fto “tg
“91
Niqumphosphat and little ammonium ‘
@ cUoria at Alphen, Robert ‘R’ 54 [1935] 361 ’364)’
KPgo: 139o ‘. A. o:-rr: i ^ * r ^ raan’lan Artilzel erha.ltene Ver-
On heating at 210o Torr 2b is obtained in the following article vei
binding

We got a little bit of help with the words, not much.  Beilstein is such a reference as to be the last word, whatever the chemical, from a literature search beginning with the literature from the beginning.  You’ll call on it for any chemical in stock.  Tells how to make it.

“Synthese” is “synthesis”, or, I guess, “zuchtung” is, so, ferret out that word.  Oh, the translation problem has been ferruled for just this source before.  This handbook has handbooks.

Here’s one: http://www-sul.stanford.edu/depts/swain/beilstein/bedict1.html

Two-way glossary of organic chemistry terminology.

I’m on my way to UCSD for blolood work for an upcoming PET scan, but, I don’t want to go to that library full of Japs.  I gave it one last shot.  I haven’t been hitting.  Today, gold:

http://vanilla47.com/PDFs/ClandestineChemistry/Amphetamine/Beilstein-Erganzungswerk-III-(1930-)-Band-12-p2664-77.PDF

I was stuck, see?  I would have posted sooner.  Good thing I tried one last time.

What about working with this information?  You comb through it, every last drop.  It’s kind of like, when you fail, begin to read the instructions.  The only other thing is the Poseidon adventure of what to do when these links all break.  It works for today.  It works fine for people living on borrowed time.  You got Tourrette’s.

http://vanilla47.com/Chemistry1.html

I know.  Whoops One and Two has justified the proof (that’s the page).  This one above is the erowid where

it isn’t Erowid.  It reminds me of Erowid, it’s so extensive.  It’s not good weather for bookworms.  I’m not going to stand in front of that obelisk-shaped bookshelf without a wingman.  The indices are wicked to go back and forth.  But, the single number I’d carry in there is

4-12-00-02589.

I had to get it from a previous post of mine.  That’s what I mean.  If I go in there, I don’t wander around.  I state, “methamphetamine” to the reference librarian, and, I don’t threaten her.  But, hey, I’m doing this.  I had to know if my country was going soft in the head, and still think I was cooking.

That deal breaks down according to some instructions, take these:

http://www.asu.edu/lib/noble/chem/beilstein.htm

Thank you.  These people will be lying, and, this is the kind of stuff to throw back at ‘em.  The ref# says where to look, like, the 4 is volume four of a “hauptwerk”.  Maybe.  I don’t have ti

 

 

Replacing Reducing Agents Via Organic Electrochemistry

Hydrogenators are suspicious (source: DEA list of chemicals).

This is the second time through.

I am going to do it differently.

h

ell, what the…  Last time, I come out with nothing but a title.

jjj

esus.  All that scanning, all that uploading.  “What you want is a gallery.”  No, I can’t upload on edit no matter what, the images unsynch and duplicate.

Naof

uck you.  I don’t even have a cup.  Kick me as hard as you can in the balls.

Ph

uck.  I just wanna do all sorts of gay shit.  I am getting the rhythm going.

I know that I am basically going to get you to a picture of the cup.  This here is for when you test out -Cl removal, hydrogenolysis, in adjustable-voltage mode, you will have a ball-park for that, whether it’s easy or hard.  It should be easy.  It’s a benzylic halide.  I plot my learning curve such that a system requires apparatus.  I don’t worry what it looks like with or without calculus.  I got Halliday and Resnick at this point..Volume I: measurement, Motion along a straight line, etc.  and Volume 2, electric charge, electric fields.  How do you like that electric charge?  I like it fine.  That’s what the capacitor’s for.  Here, fuck.

I got a bad feelin’ about this.

I’m not just going to beat you on how to make M3HT.  I’m going to teach you how to fuck:  Don’t sit there getting horny if you’re HIV+.  Seek out the host and say, “I need to fuck.  Can I use your bedroom?”  No, I have a bad feeling.  Am I not going to be able to upload the missing pages if I forgot any?  Hmm.  Chalk this one up to good-old WordPress leaving you severed.  If I ask for a page I expect that page, not the awareness of someone’s DNA curling up in a

[inserting 4-5.  I didn't mean differently bad; I meant an improvement.  But, do I improve it?  idk, WP's little program tends to wash you out to sea if you are talking.  It sent it to the trash.  I had to carefully undo.  I'll have to see what happens.  You can't mess it up if may always die whilst adding a piece to it.  My next operation in time is to add the missing image, #4, the fifth one.  The right Amico is the next tasking on the scanner; I don't like publishing my address to make a point. ]  word count went from 314 to 411…what is ‘word’ blue for . Blue?  How many bytes to color something…

Rame

Total Entries: 563   Xv Monday, 3/14/11, 9:09 AM     King, I haven’t heard from God for a good while. He sent me an email saying he was headed my way. That was at the very end of February, and I haven’t heard from him since.     503 Sunday, 3/13/11, 1:13 PM     What up King?? Been awhile     King Sunday, 3/13/11, 11:59 AM     GOD     Need2know Sunday, 3/13/11, 9:13 AM     Does anyone here know how to extract MDMA from Vitamin C used as the cut? To dissolve one or the other leaving the MDMA     Xv Tuesday, 3/8/11, 1:59 PM     I actually fumbled with that choice of words. I was going to go with “the active hydrogen produced *at* the palladium black catalyst”, but alas. Anyways, I discovered “Lucas’ Reagent” (conc. HCl/ZnCl2 solution) which chlorinates ephedrine. The ZnCl2, however, tends to sludge up upon basing to extract the ephedrine therefrom. Apparently this is worked around by basing with sodium carbonate until fizzing upon addition ceases, and then hitting the solution with NaOH to break the sludged out ZnCl2 down into Zincate. I’m just going by what I’ve read, however. I’ve yet to see this in action, but I’m working my way there. Pops/503, the person that posts on here as “god” educates people on a method of obtaining clean ephedrine by simply soaking ground-up/powdered pills in methanol in the freezer for three hours, filtering, drying the filtrate, and repeating the process three or four times to further clean the pill mass. My experience with this is that the residue left after drying the filtrate isn’t all that clean, and I’ve done no further testing to verify that it is indeed only ephedrine with no byproducts or contaminants. It also doesn’t produce a crystal clear solution when mixed with a solvent; it’s cloudy, which indicates to *me* that it’s not pure ephedrine which is appreciably soluble in water. Anyways, I was wondering what you guys think of this method of extracting pure ephedrine from pills. My thoughts are that Uncle Fester spends a majority of his time developing methods for obtaining clean ephedrine from each new pill formulation designed to prevent such, and the mere fact that a simple methanol soak, filter and drying isn’t given mention in any of his books is clear evidence that it’s not a viable method. Granted, I haven’t tested the resulting residue to be at all certain, but that’s just my opinion on the topic; I want to hear from you guys.     Pops Tuesday, 3/8/11, 12:40 PM     Whoa, back the truck up. “the active hydrogen produced by palladium black catalyst” is a poor choice of words. You know SWIM will have to get something to go with his Pd and that’s hydrogen gas? I estimate 2 or 3 atmospheres. IOW, first you want to leave out the chlorination step, leaving out hydrogen gas you’re really dreaming. C- OH, to break that bond between carbon and the heteroatom oxygen is called hydrogenolysis, a sub- category of hydrogenation. Under that entry, flow hydrogenation is mentioned. That might be good. — ————————— On the one question what might be good on account of PCl5 and SOCl2 being watched, obviously there are two approaches. Out of what I have, what does it best, and, what does it to (this substrate) my starting material? “Reagents” by Fieser and Fieser, tells you all about something you think is banging. I’d want to go through all my hypochlorites and sulfur chlorides in there, then there’s chlorine produced at an electrode, … which is an active chlorine. Active hydrogen is actually coming off a cathode, any, which you may be thinking of. Palladium holds more hydrogen in its lattice than any other element, because, because … You heard about palladium electrodes because of this property. Please read http://en.wikipedia.org/wiki/Hydrogenation     Pops Tuesday, 3/8/11, 11:47 AM     As to whether palladium in any form will reduce ephedrine directly idk. Jaguar Dave said he was doing it that way in 1985 (San Diego). I went there (North Park). He had a kettle-type flask under heat in the closet, with the thermomether reading 175 degrees. I couldn’t even find a solvent that boils at that temp, like, I guess some derivative of acetic acid does, but … Dave didn’t like to be questioned much, and he carried some silly little pistol. I didn’t get to be there from start to finish. he used the term, “palladium black”. When I came back once his neighbor, a kid, who knew what he was up to said he was just there, but he “was not here to function”, like, he was spun. Dave used to give me a hit of his stuff for free every day. It was like white mud, not overly strong. tasting like popcorn oil.     Xv Sunday, 3/6/11, 8:55 PM     Scratch my first question. I now see that both Phosphorus Pentachloride, as well as Thionyl Chloride, are on the watch list. I understand that Phosphorus Trichloride can be made into PCl5 but hitting it with dry chlorine gas. Pops/503, do you either of you have any insight into this that you could offer? On another note, is there another conventional method available for chlorination in a home lab? -or- will the active hydrogen produced by palladium black catalyst reduce *non-chloro* ephedrine/pseudoephedrine, or will it only reduce if the precursor is chlorinated?     Xv Saturday, 3/5/11, 10:46 AM     Another quick question – does anyone have any experience in methylation? Fester’s Advanced Techniques describes the extraction of amphetamine from Adderall tablets, and subsequent methylation of the extracted amphetamine to methamphetamine. I can’t remember exactly what the process is… I believe formaldehyde, zinc dust and dil. glacial acetic acid are heated to boil for a few hours to methylate the amine, which is subsequently extracted out and gassed.     Xv Saturday, 3/5/11, 10:42 AM     Quick question. Are purchases of Palladium Chloride and Phosphorous Pentachloride brought under any scrutiny?     503 Friday, 3/4/11, 9:58 PM     GOD,Pops thanks for the clues… I finally found what I was looking for now what should I do? LOL     503 Friday, 3/4/11, 9:50 PM     To a large measure, this —- has emphasized the “phenyl” end of the phenethylamine molecule, and the “what,” the “where,” and the “how many” of the substituent groups involved. There is a broad variety of chemical groups that can be attached to the benzene ring, at one or more of the five available positions, and in an unending number of combinations. And, in any given molecule, the greater the number of substituents on the benzene ring, the greater the likelihood that there will be psychedelic action rather that stimulant action. But what can be said about the “ethylamine” end of the phenethylamine molecule? This is the veritable backbone that holds everything together, and simple changes here can produce new prototypes that can serve as starting points for the substituent game on the benzene ring. Thus, just as there is a “family” of compounds based on the foundation of phenethylamine itself, there is an equally varied and rich “families” of other compounds that might be based on some phenethylamine with a small modification to its backbone. So, for the moment, leave the aromatic ring alone, and let us explore simple changes in the ethylamine chain itself. And the simplest structural unit of change is a single carbon atom, called the methyl group. Where can it be placed? The adding of a methyl group adjacent to the amine produces phenylisopropylamine, or amphetamine. This has been exploited already as one of the richest families of psychedelic drugs; and over half of the recipes — —- – are specifically for amphetamine analogues with various substituents on the aromatic ring. The further methylation of amphetamine with yet another methyl group, this time on the nitrogen atom, yields methamphetamine. Here the track record with various substituents on the aromatic ring is not nearly as good. Many have been explored and, with one exception, the quality and potency of human activity is down. But the one exception, the N-methyl analogue of MDA, proved to be the most remarkable MDMA.     Xv Friday, 3/4/11, 10:45 AM     Yes, but not ‘Doctor Howdy’. When I first began posting, I used the alias ‘Dr. Kenneth Noisewater’ (which isn’t my real name obviously; it’s just a reference from the movie ‘Anchorman: The Legend of Ron Burgundy’). The person that posts as ‘God’ just began to call me ‘doc’ at some point.     503 Friday, 3/4/11, 5:57 AM     XV are you the one they call doc if I can ask?     503 Friday, 3/4/11, 5:56 AM     Man I was looking through old zone 86 archives and it seems like weve came a long way, but there are a lot of interesting GB thoughts to expand ideas even if they are not correct. Doctor Howdy Sunday, 9/14/08, 1:43 PM The Anarchist Cookbook is shit it leaves out key steps don’t waste your money.The only leading authority on real recipes is Uncle Fester(Alexander Shulgin),but you need to be able to understand real chemistry and have the proper tools too!But his shit is real and people have been using it for years.So Bro those are your choices either way you are gonna have to learn some stuff.I’ll help you any way I can but I only know so much.The Doctor……     Xv Thursday, 3/3/11, 8:19 PM     Wack-a-Mole: Safrole Edition ™. Is that excerpted from The Hive’s archives?       Thursday, 3/3/11, 7:45 PM     not the sort of industrial-scale visions a bee might have. For instance, how much current can the system withstand? How well does it scale up? A reasonably sized aparatus capable of Wacking a whole mole of safrole (~190g) might be achieved with 30 amps (@3 volts) in about 2-3 hours. Ahh, but what bored bee will do the experiment? And how should the cell be built? Bob likes glass (any old cooking pan may work), but what material should be used for the electrodes?) Putting together this unusual power supply would also be a nuisance, but certainly no great obstacle to the electronics geeks. Bob is also semi-concerned about the high palladium:olefin ratio (1:20) but the palladium appears to recover and recycle well, and the ratio might be lowerable without adverse effect. On the bright side, Bob is 99% sure this thing could be scaled waaaay up.)     503 Thursday, 3/3/11, 7:39 PM     The Wacker type process with palladium(II) chloride and copper(II) as catalysts in aqueous media under oxygen (Bob: Which is to say, the famous O2 wacker) is one of the useful methods for conversion of terminal olefins to methyl ketones (#1). A variety of modified methods of this reaction by devising the reoxidation process for palladium(0) to palladium(II) have been reported in order to avoid chlorination encountered in the process with copper(II) chloride (#2). Electrooxidation methods were also employed for the direct oxidation of Pd(0) to Pd(II) (#3) or for generation of recyclable oxidents such as quinone (#4) or ferric chloride (#5) as a co-oxidant for regeneration of Pd(II) catalyst. Usually divided cell systems have been utilized to avoid the deposition of palladium metal onto the cathode, which often led to unsatisfactory reaction conversion. (#6) Herein, we report an improved procedure for the electrochemical Wacker type reaction by use of triarylamine as a recyclable mediator (#7) for regeneration of Pd(II) from Pd (0). The electrolysis can be achieved in both a divided or an undivided cells. In this double mediatory system, electrooxidation effects formation of triarylamine cation radical from triarylamine which regenerates palladium(II) species. [diagram] The cation radicals of triarylamines are stable (#8) and hence useful as redox catalysts for indirect electrooxidations such as deprotonation and irreversible cleavage of carbon-sulfur bond (#7). Redox step by the cation radical of triarylamine is considered to involve the formation of an intermediate complex, which would lead to a negative shift of the oxidation potential compared with those of the substrates. (#9) These features of the cation radicals of triarylamines are of interest as a recyclable organic redox for regeneration of Pd(II) from Pd(0) in the double mediatory system. (Bob tries to translate: The electricity flowing through the solution converts the triarylamine into a radical (positively charged ion). The palladium is being converted from it’s Pd(II) form to Pd(0) when it converts the safrole into MDP2P ketone. The triarylamine radicals then react with the the Pd(0), turning the palladium back into it’s catalytically usefull Pd(II) form, and in the process the radicals get converted back to plain old triarylamine. The process repeats itself as long as the safrole and electricity last. The electrolyses were carried out either in a divided or undivided cell under a constant applied voltage. Typically, the electrolysis in an undivided cell was performed by using the substrate (1 mmol), PdCl2 (5 mol%), and (4-BrC6H4)3N (5 mol%) in an MeCN-H20 (7:1)-(Pt)- (Pt) system at an applied voltage of 3 volts and a current of 2-3 milliamps for 2-3 Faradays/mol, giving the desired methyl ketones. The results of the electrochemical Wacker oxidations are given in Table 2. (Bob: A Faraday is one mole of electrons (ie. it’s a measurement of how much electricity flows through based on the ammount of current and how long it flows for.) To calculate F, you take amps of current * time in seconds / 96,500. So, 10 mA of power flowing for one hour (3600 seconds) gives us ( 0.010 amps * 3600 sec/96500 conversion factor), which comes out to a wretched .00037 Faradays (moles of electrons.) Note that the reaction is described in terms of F/mole of olefin, which is only logical (the more material processed the more electrons needed.) What this means is that if you want to process .01 moles (just under 2 grams) of safrole, you’ll need to leave on that 10 mA current for about 50 to 80 hours. Now, I’m sure your first impulse is to say ‘scew that’, but the methods and cells used by these scientists were tiny experimental ones, not the sort of industrial-scale vis     Xv Thursday, 3/3/11, 6:16 PM     I actually read Advanced Techniques 2 for about a half hour tonight. I only read the chapters on ‘Preparation of PlCl2′ and ‘The Fester Formulas’ (I didn’t have time to finish the latter). The first portion of the latter dealt a lot with converting chloroephed to meth by cooking a solution of chloroephed, PlCl2 and aluminum powder in conc. HCl. Like I said though, I didn’t finish; I’m sure there are better techniques later in the chapter.     503 Thursday, 3/3/11, 4:45 PM     Here is another option for you XV Palladium on Carbon (5% Pd/C) [1] Prepare a solution of 1.7 g of Palladium Chloride (or an equimolar amount of palladium chloride dihydrate, PdCl2*2H2O) in 1.7 ml of concentrated hydrochloric acid and 20 ml of water by heating on a water bath for 2 hours or until solution is complete, and add this to a solution of 30 g of sodium acetate trihydrate (Note 1) in 200 ml of water contained in a 500 ml hydrogenation flask. Add 20 g of acid washed activated charcoal (Note 2) and hydrogenate in an atmospheric hydrogenation apparatus until absorption ceases. Collect the catalyst on a buchner funnel and wash it with five 100 ml portions of water and suck dry as possible. Dry the catalyst at room temperature over potassium hydroxide pellets or anhydrous calcium chloride in a vacuum dessicator. Powder the catalyst (approx 20 g yield) and store in a tightly stoppered glass bottle. Alternate procedure [2] Heat 7.5g activated charcoal (Note 2) on a steam bath for 2-3 hours with conc. hydrochloric acid (5 ml) and water (150 ml). Wash the charcoal by decantation with hot water until free of acid, filter it off, and dry it in an oven below 100°C. Heat palladium chloride (0.5 g) in conc. hydrochloric acid (0.75 ml) and water (5 ml) on the steam bath for ~20 min. Add the solution to AnalaR sodium acetate (17.5 g) in water (50 ml) contained in a hydrogenation flask. Introduce the purified charcoal (5.8 g) and hydrogenate the mixture until no more hydrogen is absorbed (~2 h). Collect the catalyst on a 7 cm Buchner filter (3 thicknesses of Whatman No. 1 filter paper), wash it with water (5 x 100 ml) and drain it on the filter with suction. Dry the catalyst over fresh silica gel in a vacuum desiccator and store it in a tightly stoppered bottle.     Xv Thursday, 3/3/11, 11:23 AM     Yeah, I actually told my wife, who’s been trying to get me to sell off all of my lab-ware, that I was going to sell it and buy an ounce of palladium with a portion of the proceeds. I’ve been dying to test this out for months.     503 Thursday, 3/3/11, 10:17 AM     In my opinion electrolysis is the only way to go because most things needed are easy to get and youre not looked at funny while buying. Also I dont see how the gov can ever stop it maybe thats why its a myth… Pops,God or anyone with info on this subject would be appreciated.     Xv Thursday, 3/3/11, 9:25 AM     I actually haven’t studied anything at all in a while. All of my books are on my laptop, which has been in the shop getting its keyboard replaced for the past three weeks. I can feel myself getting dumber and less intuitive by the second.     Xv Thursday, 3/3/11, 9:23 AM     That depends. I’m not sure what you mean by ‘primary’ and ‘secondary’ Sorry, just woke up. Too groggy to try to remember what I said.     503 Thursday, 3/3/11, 12:36 AM     XV you can substitute many things thats how words got twisted and people started down wrong road. All that really matters is primary, secondary… and the right cataylist to match what your oxidizing and reducing but Im sure you already knew this?     503 Thursday, 3/3/11, 12:26 AM     Not to sure XV to be honest but I know one thing for sure swim has finally found that easter bunny…     Xv Wednesday, 3/2/11, 8:54 PM     Is that from the 1st edition or the 2nd, 503? Fester had mentioned to me that the palladium was no longer a necessity of the Fester Formula according to the 2nd edition, but I haven’t noticed a difference between the Fester Formulas in the 1st and 2nd editions besides the incorporation of Emde’s electrolytic hydrogenation of chloroephedrine / chloropseudoephedrine, although I concede that I haven’t yet had the time to *thoroughly* dissect the FF detailed in the 2nd edition quite yet.     503 Wednesday, 3/2/11, 7:02 PM     The process of anodizing the palladium will have to be repeated prior to each run. Some fresh metal may have to be exposed on occasion by light sanding of the metal surface. An ingot of palladium should last for a lifetime. The reaction mixture should be poured into a sep funnel, and a 20 % NaOH solution should be added with shaking until the solution is strongly (13 + pH) alkaline to pH paper. Extract with two 50 to 100 mL portions of toluene. This should be plenty for one-gram of product. THe toluene extracts are then bubbled with dry HCl to get the crystalline hydrochloride product. After rinsing them off with some fresh toluene, they are spread out to dry. The most pleasantly surprising finding is that crank produced by this method doesn’t give one the body and soul- wrenching hangovers so typical of the product made by the iodine-red phosphorous method.. This is a highly desirable way to keep one’s own party rocking and rolling. If one should wish to produce more than a gram or so at a time, a larger palladium cathode should be used. Linking together more ingots of palladium would get pretty expensive, so a more economical alternative will be detailed. That alternative is electroplating some copper or brass screen with a thick coating of palladium. The simplest way to get this section of screen electroplated with palladium is to go to the yellow pages, look under electroplaters and find one who plates palladium. Ask for a plate build-up of several thousandths of an inch, so that enough Pd is deposited to last a while.. The Pd plated screen would then be used exactly like the ingot. First it must be anodized, then charged up with hydrogen in exactly the same way. The sole difference is that the greater surface area of the screen facing the condom-encased anode requires a correspondingly greater amount of current to be passed. Then, during the course of the reduction, again 50 milliamps per square centimeter of surface area facing the anode is used. The total of 3000 or so coulombs per gram of feed material doesn’t change by increasing the size of the electrode. An alternative to this is plating the screen yourself, anodically dissolving a portion of the ingot to form a PdCl2 solution then….. sorry folks, this all of the manuscript I have, but I’m sure palladium plating is no national secret (yet). There is a company that sells an electroplating kit consisitin of a power supply, metal solution and a ‘pen’ electrode. As soon as I find their paperwork among my rubble I will post it. The lastest word from Fester is a couple of references from Indian journals on electroplating graphite electrodes with palladium, essentially giving a Pd black on C catalyst in the cell!     503 Wednesday, 3/2/11, 7:00 PM     Oxygen will bubble freely from the ingot, and hydrogen from the piece of lead. Blackening will be noted on the edges of the ingot, where the current is most intense, and a lighter discoloration on the flat face of the ingot. This pre-treatment is called anodizing. It has been found that anodizing increases the ability of the palladium ingot to adsorb hydrogen when the wiring is turned around, and the ingot is made the cathode. Next, redo the wiring so that the palladium ingot is attached to the negative pole of the DC power supply, and the piece of lead to the positive. Turn the juice back on and run between one and two amps of current for about 20 minutes. At first, the amount of hydrogen generated at the palladium ingot will appear small. This is because the Pd adsorbs hydrogen so well. After about five minutes of current passage, the whole surface of the ingot will freely bubble off hydrogen. After the 20 minute charging with hydrogen, begin magnetic stirring of the solution, and pour in about half of the ester reaction mixture from the large test tube. Adjust the current flow from the variable power supply so that a current of about 50 milliamps per square centimeter of palladium surface flows. If one has about six square centimeters of the ingot facing the piece of lead immersed in the solution, a current of about 300 milliamps is called for. This will result in some gassing off of hydrogen from the edges of the ingot, but over the rest of its surface the hydrogen will react before it bubbles off. The lead anode will form a brown layer of lead oxide, and will not dissolve at all in the sulfuric acid solution. Some surface particles will be kicked off the lead when it’s first charging, but they don’t make it through the condom. The lead anode can be replace with a piece of platinum if desired, but lead is a lot cheaper. Graphite is amother possibilty. Keep an eye on the current meter, as the current flow can change as the reaction progresses. Keep the current flow around 300 mA (0.3 amp) for the size ingot given in this example. When 1000 coulombs ( a coulomb is a unit of charge equalling one amp-second) have passed into the solution, add the other half of the ester reaction mixture from the test-tube., and continue at 300 milliamps until 3000 coulombs have passed through the solution. Let us use the 300 mA current to show an example of these calculations: At 300 milliamps, 1000 coulombs pass in 1000 / 0.3 Amps = 3333 seconds, or a little under one hour. 3000 coulombs pass in 10,000 seconds, or two hours, 45 minutes. 3000 coulombs per gram of feed material has been found to give good yields of a fine product, but by no means consider this number to be optimal. It may well be that a greater yield would be obtained by passing more current. It may also be that pseudoephedrine and PPA differ from ephedrine in their ease of electrocatalytid hydrogenation. I don’t think that any harm can come from passing more current, within reasonable limits, so by all means experiment with the amount of current passed. During the course of thi reduction, the color slowly changes from its initially clear color to slightly tinted with yellow. It’s not known whether this color change is due to some of the condom soaking out, or if it’s a byproduct of the reaction. In any case, it’s a remarkably clean reaction. When the desired amount of current has passed, the work-up and isolation of the product is very simple. The Kling- Tite condom is removed from the beaker. after pulling out (no pun intended) the lead electrode, the jimmy hat is, as is custom in some parts, flushed down the toilet. The anode can be used over and over. The palladium cathode is then rmoved and rinsed off. It too can be reused an INNUMERABLE (Bozakium’s emphasis) number     503 Wednesday, 3/2/11, 6:57 PM     Reduction of the hydroxyl group of various 1-phenyl-2-aminopropanols and their substituted amino variants are easily and efficiently carried out by electrocatalytic hydrogenation of their respective acetic esters at a palladium or palladium-plated electrode in a divided electrolytic cell. Use of a lamb’s skin prophylactic as an inexpensive yet effective cell divider is also demonstrated in this experiment. Materials: One (1) gram of purified ephedrine, pseudoephedrine or phenylpropanolamine. One troy ounce ingot of palladium Glacial acetic acid Concentrated sulfuric acid Sodium hydroxide Anhydrous HCl gas source pH-indicating paper Toluene Kling-Tite Naturalamb brand condoms Lead or graphite electrode 1/2-inch wide by five inches long Six one-inch alligator clips Several feet of 16 to 20 gauge insulated copper wire Variable DC power supply Ammeter capable of measuring up to 3 amps, with resoloution to 1/10 of an amp Voltmeter (optional) Procedure: One gram of ephedrine, pseudoephedrine or PPA hydrochloride is placed in a large test-tube along with 5-7 mL of glacial acetic acid. The test tube is heated in a water bath until all the ephedrine(in this case) hydrochloride is dissolved. A few drops of concentrated sulfuric acid are added. Mix it all together and LOOSELY stopper the end of the test tube to prevent steam from entering. Heat the water bath to just about boiling, and use it to heat the test tube and its contents for a few hours. This forms the acetic ester of the ephedrine, pseudoephedrine or PPA used in the reaction. The solution should appear clear and water- like, completely homogenous. After heating, the reaction mixture can be kept stoppered as is for a few days, but it’s best to use it immediately after it’s cooked. Next, mix up a solution of 5 mL of concentrated sulfuric acid in 100 mL of water. Take a 250 mL beaker, and place it on a magnetic stirrer. Clip a well-scrubbed Kling-Tite Naturalamb condom in one side of the beaker, and place a piece of lead 1/2 inch in diameter and a few iches long inside the condom. On the other side of the beaker, stand up a one-ounce ingot of palladium. Using alligator clips, make contact with the ingot, and wth the piece of lead. They are your two electrodes. Next, pour most of the dilute sulfuric acid solution into the beaker. Save enough that some can be poured into the condom so that the solution levels are about equal inside the condom and the beaker. The ingot of palladium should be almost completely immersed. The alligator clip should be up out of the solution, and there should be enough space left to add the ester reaction mixture from the test tube to te beaker without causing the solution level to reach the alligator clip. The surface of the palladium ingot should be lightly sanded prior to use. This increases its surface area a little and exposes fresh, clean metal. The piece of lead should be scrubbed free of grease and dirt. The wire lead to the palladium ingot can be clipped to the side of the beaker with a clothes pin or paper clip to prevent the ingot from falling over during the course of the reaction. A DC current meter (ammeter) should be put in series with the wiring. A good one can be had at Radio Shack for under $50.00. The wires are first hooked up so that the palladium ingot is connected to the positive pole of the DC power supply, and the piece of lead to the negative. The typical one- ounce ingot will have a face with an area of about six square centimeters immersed in the solution and one square centimeter up out of the solutuion. Only count the area on the side facing the lead piece. The back side doesn’t count because significant current doesn’t reach it. With this typical ingot apply about two amps for 30 seconds to one minute. Oxygen wi
	Xv	Wednesday, 3/2/11, 5:04 PM
	Electrolysis definitely doesn’t get the attention that it deserves, and I’m not sure why, because you would think that as “clandestine” chemistry goes, you want to be as low-profile as possible, and purchasing (or stealing) 10 liters of 2% Tincture of Iodine and 1,000 boxes of matchbooks is, at first glance, a little less low-key than is purchasing a bottle of HCl or H2SO4 from the hardware store (or, in this instance, mercury from the shops you mentioned, which are certainly more obscure than wherever it is that people buy their RP/I2).
	503	Wednesday, 3/2/11, 2:55 PM
	occur (production of the alkene, for example) my guess is that the abstracted hydroxyl is mainly converted to water. > What is used to extract the desired product – HCL gas as usual? Since you basically now have a solution of an amine in acid, it seems like basification & extraction followed by precipitation with HCl would be appropriate. > What should the pH of the solution be? I’m assuming that the “dilute” acid would be around 20%? I generally consider “dilute” to be less than 5%. In “Psychedelic Chemistry” where this method is used for the reduction of nitro to amine the anolyte is 3 N H2SO4 and the the catholyte (which in a reduction contains the reactant) is more dilute. Since the acid mainly functions as an electrolyte in this procedure and excessive acid could damage either the reactant or the product, the lowest concentration sufficient to maintain a reasonable current should be used. Smaller cells will need lower concentrations. High acid concentration would also make the product work- up less convenient. Products should be carefully purified (recrystallized, perhaps twice) to eliminate the possibility of lead or mercury contamination. BTW, It is entirely possible that different electrode materials could be used – they often are, depending on the potentials required. The only requirement is that the hydrogen overvoltage exceed the potential required for the reduction (assuming a protic reaction medium). Mercury is commonly used because it has the highest hydrogen overvoltage. Other cathode materials to try might include lead, tin and copper (often used for reduction of nitro cpds), cadmium or cadmium plate. Alternative anode materials may include platinum, carbon, and nickel. If someone has a laboratory available it would be quite useful to determine the actual reduction potential required (cathode versus a standard electrode – use a pH/mv meter). This would greatly aid in the selection of materials and optimization of the procedure. Electrolytic reductions and oxidations are of very general application. I suspect that a number of procedures given in PIHKAL and TIHKAL could be carried out electrolytically in a much simplified manner.
	503	Wednesday, 3/2/11, 2:52 PM
	While I was catching up with you guys I stumbled upon this, The recipe read: > > > > <<<<<<<>>>>>>>>> > > The process has been proven on a very small scale, but could be > > scaled up to gigantic proportions. > > ————————- > > > > Apparatus: > > > > Purchase a clay pot and using GE Silicone II plug up the bottom > > hole; and coat the bottom 1/2 inch of the pot with the silicone. > > > > Purchase a tupperware container of the same depth as the pot and > > large enough in diameter to set the pot in the middle with room > > around the outside for electrolyte. > > > > Purchase a box of lead wire approx 1/4 inch diameter as sold in > > fishing supply stores. > > > > Purchase a 110VAC 10A max variac. Construct a recifier using a > > bridge rectifier so that the variac output is converted to DC. > > Put a 0-10A meter in the rectifier box. Put two wires with large > > alligator clips on it for the DC output. > > > > Purchase a few feet of teflon insulated wire, at least 22ga. > > > > ————– > > > > Chemicals Needed: > > > > Utter simplicity- ephedrine/pseudoephedrine chloride or sulfate. > > Hydrochloric or sulphuric acid. Mercury. Mercury can be bought > > from mining or rockhound supply stores, or salvaged out of old > > electrical relays. Or from your friendly chemical resale house > > who will probably soon be selling it. > > > > ————— > > > > Process: > > > > Add mercury to the clay pot. Just enough is needed to cover the > > bottom surface. > > > > Put the clay pot in the middle of the tupperware container. > > Prepare a mixture of ephedrine salt and dilute acid (either HCl > > or H2SO4) and fill the pot to within 1 inch of top. > > > > Fill the outer tupperware container with dilute acid to within 1 > > inch of the top. > > > > Make the positive (anode) electrode by spiraling the lead wire > > around the outside of the tupperware container to make a complete > > circle, and then hang it over the edge so that the clip can make > > contact. > > > > Scrape 1/2 in insulation off of the teflon wire and immerse it > > in the mercury. Make certain the electrolyte only contacts the > > insulation. This is the negative electrode (cathode). > > > > Hook the anode to the + or positive clamp from the rectifier and > > hook the cathode to the – or negative clamp. > > > > ———————————– > > > > Conversion: > > > > Slowly adjust the variac so that the meter registers 4A. > > Be careful not to touch the terminals since one side is at the > > hot side of the AC line. > > > > Wait a while, and adjust the variac to that there is vigorous > > bubbling, yet no boiling of the cathodic liquid. > > > > After 6-12 hours, stop the process. > > > > The liquid inside the pot is a solution of methamphetamine salt. > > > > —————————– > > > > Note, the process also works for convering psychedelic > > nitrostyrenes or B-nitro-safrole to the amine. Alcohol and > > acetic acid will be needed to dissolve acid and olefin. > > <<<<<<<>>>>>>>>> > > > > Is this a trick or what? > > I’m curious about the solution in the pot after the conversion. Although side reactions can o

Ethyl Acetoacetate, Bromobenzene, to make Phenyl-2-Propanone

This is the meth total synthesis which does not go back steps to phenylacetic acid, in a long post on a dope website called Hip, or something.  I am linking it here to take you there.

I read it, or, skimmed it.  I notice a sodium metal + ethanol part, to make sodium ethoxide.  You notice that, since chemicals like that represent potential trouble.  You have to be able to squeak some product out, and, if none comes out, you have to investigate every assumption; one or more of them was a mistake.

With this one, the ideal of producing meth from smaller and untraceable fragments appears attainable.

“Acetoacetic ester” is the name of the synthesis, and ethyl acetoacetate (EAA) just means the ethyl ester of acetoacetic acid.  This acid has two neighboring carbonyl groups, like pyruvic acid.  Acetoacetate, notice, has ‘acet’ twice, for a relationship to acetic acid, a two-carbon carboxylic acid.  ‘Ethyl’  also denotes two carbons.  A methyl ketone, a formal derivative of acetone, is the product, and so is a natural way to make P2P, aka phenylacetone.

I don’t know how well it works.  It might be the old CIA method (which I wrote about), and, I am comparing methods I have never tried.

EAA might be on the DEA watch list of chemicals, so, it needs a synthesis.  These kinds of things are right for ton quantities deep in Mexico, but for sure, I don’t want to write an irrelevant blog where somewhere in the world someone has a “magical” meth synthesis I am clueless about.  I understand as of today that blogging is a rather phony deal because the world of publications is about something worth reading, not something worth doing (“is worth doing well”).  The ‘send’ button of an e-mail is re-labelled, “publish”.  This causes the consumer of computer products to subscribe to the illusion that he or she is a supplier.

317

I better quit, it’s late, before it gets to 917.  The chemical appears not to be watched on this list.

I checked the link, and caught another word for the same thing I didn’t use: Beta-keto esters, which also fits in nomenclature.  An ester has a carbonyl group, the two-bonded thing to oxygen (=O), but usu seen sticking up, and that carbon is zero, alpha to it is next to it, and beta (usu seen as the German, well, Greek, letter B), is next to that.  Now, P2P is a desired intermediate, and any other configuration is permanently hexed, can’t be made out of.  The phenyl ring is beta to the carbonyl in P2P.  Amphetamines are beta-phenyl ethylamines, where the zero carbon bears the amine, the ammonia moiety, the nitrogen, etc.  The common talk, words like “nitro-keto alcohol”, are the ones used in the 1950s by Gordon H. Alles of Caltech, who patented and made possible the amphetamine explosion in use.  I don’t know, some of it might go back to 1938.

487

Actually, the technology peaked at HI/red P, making a vitreous poison that smokes when you crush the crystals, using nothing but nutrients.  Nonsterile?  Naw, it’s heavy-metal toxins we do not have.  When I heard this I almost believed in miracles.  If miracles exist, this is one.  That’s all you gonna do.  We have set it to benefit us, who cares if it takes a long time, who cares if it’s expensive.  It’s the tweaker’s dream, not a commercial enterprise in order, teleologically, to rip off the customer by sacrificing his life he doesn’t even know.  It’s found us and we are intrinsically running our own route.  Look no further.  How do you make amphetamine?  Doesn’t matter, it’s a drug on the market.

610

We Were Talking About the Love Between Us All

We weren’t; oz just—

I was just—

freaking out.  I lost all this for a second, and it was good:

Yes. I think the man is holding a fifty-liter; the smaller ones are 22s. There is red phosphorus residue inside, and the center hole is flanged. The lid(s) available can have different numbers of different size standard taper female necks, or female spherical joints. A cheaper flask than that one would have ground glass:
http://en.wikipedia.org/wiki/Ground_glass_joint
But this doesn’t show wrapping with teflon tape. TFE tape for plumbers is fine for a dollar, and a more expensive roll for labs is thicker and about 3/4″ wide. As soon as I buy ground glass, I wrap tape around the male joint. If it is stretched it sticks. I never use grease, but in education, we are told to use high-vaccuum grease for the same reason (to not let the pieces freeze together). We never leave eqpt assembled. Something must be used on every joint every time. Grease would just contaminate the product. In a lab course, you are not ingesting the chemicals, so grease is used. TFE tape is so thin it doesn’t interfere with the seal as long as it is laid flat in one layer. A scrap of paper will work for storage of new pieces without a trace of grease, when it is a stopper in a bottle, which is stored assembled. It is not recommended to put them together and try to pull them apart. They weld almost immediately.
The big flask can only lose the lid this way, and the condenser in the lid (or top). With a flange and matching top, a clamp with wing nuts around the circumference and a teflon gasket complete the joint. A large flanged flask is PROCESS SCALE, and lab coursework doesn’t prepare you for it. PILOT SCALE is large, but these terms are not in pharmaceuticals, but more refineries and chemical plants. Pharma has three sizes of lab, gram scale, kilo scale, and production scale.
Pouring out of a flask is only okay alone at the 12-L flask size, no larger. There are rigs for sale for pouring. They must hold the flask and heating mantle, sock style or tabletop are the two kinds of that; the rig will take the sock style. Big ones have two heating elements, so two $175 variable resisters are needed.
The red P method can be run in a single-neck flask, but the cheapest flask (with a small ground glass neck ) will not permit the hand to be put inside for cleaning. Cleaning is a must, to prevent incriminating traces. Use of a brush bent to reach upside down will rub the braided wire against the glass. Every flask has to have a cork ring sized accordingly so the round bottom doesn’t bang on the table when you set it down, or it doesn’t roll over and bang the lip. No two flasks can be stored together in a drawer, or they bang together when it’s opened, causing a star crack, maybe in both. Any flask with a star crack must be discarded. It won’t last like a windshield, you’re heating it. This big one is thicker glass, but if it were evacuated and the tech is up on a ladder, should he drop a pen out of his pocket, that could cause it to shatter. The highest death toll is a whole room full of 21-year olds who died in their sleep when the condenser water supply tubing relaxed and fell against the hot glass in the night. Our recipe passed around in the late ’80s had a cook time of a full day. It said, “can’t overcook”. We could set it up and start it, then leave it unwatched all night. But, we were sure the water pressure would not increase when nobody was using it, thereby popping off the tubing and allowing the system to heat unchecked to dryness, when the temp would go up and form the poisonous phosphene gas which escapes and kills. I have gone to some trouble to show the gas scrubber used to carry the trace phosphene down the drain with the condenser water. This amount when everything goes right is tolerable, giving you a nausea. I can do without any PH3, and I can do without ether (by using steam distillation), or any solvents, almost (a cup of acetone), to prevent burns. Cops don’t tell you this when they say this can be done by anyone with a high-school chem class, neither will DEA chemists, since these people are murderers.

Very small size equipment comes in more sizes than are in one system, while the standard taper system is foolproof. This standard taper is a decrease of one inch in diameter with ten inches of run. On my recent purchase, Chris of Amico said ground glass would only be sold to companies.
“What comany are you with now, Steve?”
“None. Private individual. Home laboratory. See that boy? He’s going to learn chemistry for fun.”
“We require a company check for ground glass.”
Every other SoCal supplier with “showroom open to the public” was compromised by their customers and smashed by the DEA. Myriad Industries closed its showroom, the owner of Tri-Ess Sciences dies in 2005, proving this was a labor of love, and it could not stay open after that. It was in Pasadena, which has more scientists per square foot than anywhere. It has Caltech and the unmanned space program of the US. Germany is cotemporaneous, and its black mark is 17 killed by stampeding at a million-person rave near Dusseldorf. The ecstasy produced in Europe is the sole reason for such gatherings. However, the US Congress is repeatedly attempting to make the Constitution illegal, using drugs as a pretext for establishing a world poice force. The first such incident was a Who concert in 1979 in Cinncinatti, with 11 trampled. “I’d walk over you to see the Who” reads a popular shirt of the time.

I went over. There won’t be any room for any more comments. Hell, lab glass is still for sale in Pas, in a surplus store on Colo Bl.

Every plating shop will go down, because there are no chemists. I liked to get a key and work at night. In the day I would show up and call OC Chemicals (just a moment)
THIS http://www.google.com/search?sourceid=navclient&ie=UTF-8&rlz=1T4GWYE_enUS285US285&q=orange+county+chemicals+santa+gertrudes

DOWN TO HERE

I was just talking off the top of my head.  Now that is a lie.  I’m always talking-off the-top-of-my head.  Have you seen Siegfried and Roy?  They made $57.5 million annually.  They don’t have your mother bent over the hood of their car in the breakdown lane of the fwy, as they are queers.  My point is that nothing has ever been taught us in college.  What you need to do is to catch the smirk on a POS administrator (like that nigger Joe Watson, “chemist”), because of your thought process making the useless nature of your education that much sweeter for him.  Nothing of any consequence is done by imparting from one primate to another.  How are you going to learn?  Nothing that pays is ever taught in a classroom anywhere on the planet Earth.  He created the hatred in you and set you up and knocked you off with prejudice just because you hate him for who he is, and it is so unnecessary.  Students are irrelevant and there are no survivors.  Well am! Shazam!  Mr. Alchemy soaks himself in jizzum.

But it’s okay.  Don’t ever use a laptop, don’t use “Google Instant”.  It instantly clears the form you were filling out.  The cursor navigates with a mind of its own.  I love WORDPRESS, which to me contains the syllable, werp.  It didn’t still disappear just because of I started with a short reply and it went on, and on (and on).  It’s here, with its pic:

http://sbillinghurst.wordpress.com/2009/09/22/things-needed-to-make-methampetamine/

But going over to here, inch up (hitch up your britches, tie off, wait), up—who’s?  Yours.  and, then, the magilla thus:

http://sbillinghurst.wordpress.com/2009/09/22/things-needed-to-make-methampetamine/aptopix-mexico-drug-war-2009-7-27-21-10-0/

See?  They are different.  The comment never would have been seen.   It was a comment just on a click on the picture.  I made it into a post.  I don’t care if it is never seen.  I only care that it appeared to get erased, and I have a little more confidence in the new post screen form, so I moved.  I’ll move, but I like to prepare for war, not get exploited by trying to use a rifle grenade launcher that looks as straight as one of W. C. Fields’ golf clubs.  The minute you get there with a million other guys is not the time to have your piece jam in the mud.  Go back and shoot the weapons designer in his factory.

1461

A rifle grenade is a grenade that uses a rifle based launcher to permit a longer effective range than would be possible if the grenade was thrown by hand. The practice of projecting grenades with rifle-mounted launchers was first widely used during World War I and continues to the present, with the term ‘rifle grenade’ now encompassing many different types of payloads including high explosive, fragmentation, and anti-tank warheads as well as concussion, smoke, incendiary, and flare missiles. Many armies have replaced rifle grenades with dedicated grenade launchers.

Many armies indeed.  Is it a rifle or a grenade launcher?  It will do neither job well.  Did Audie Murphy use that?  Well I don’t know, but he got so he could jump in a trench and shoot everybody by fast-drawing his carbine rifle, swinging it up one handed, and then he switched to something used by the enemy.  The Jerries were his enemies, but the Americans were his frenemies.  The caption for above:

M7 grenade launcher with 22 mm grenade fitted on the end of an M1 Garand rifle.

What?  Is this of Niel Garos design?  Notice that’s just “niggers” disguised.

So I seen 1-2-3-4, as 12:34 romping and frolicking away.  Oh, a hour ago.  Is when I posted, to get the pretty time.  A post of literary throat-clearing is out there naow.

The Safe Lab stopper has to do with my recent threatening, so, I’ll not publish that name, or this other name.  Happy?  But, its manufacturer was the onliest mfr to punch into the business world from the meth world.  He specialized in glass threads, and you can see teflon threads here.  the red nut is delfin or delran or delsin something, poly-something, pent-something, a polyester.  That’s not teflon.  It costs a hundred and five dollars for one.    With you as a friend he gets busted (never mind).  The problem with the two dozen he gave (another nameless) us (they are $14), is that the 125-mL ground glass flat-bottom flasks used to store the extracts in a refrigerator on a cart all popped and sharded apart at the necks upon removal of this cart from coolidge.  See, AW COCK ASS glass and teflon JESUS have unlike coefficients of expansion.  The critical step is to screw the nut down until it touches the glass of the vessel you don’t want to fracture in a kind of Charles Bronson display of strength.  He rolled them into my hand and I took them to the Process Lab as a Trojan Horse—not the only time I’ve done that—as they were testing us; I thought we were testing them.  He said this last just as I reported back this incident, not to go along with the hand when—I don’t wish to say that it would have been nice to mention this earlier, … A big deal, no.  I have a big deal one.  I didn’t do that.  This was more funny, all the bottles breaking, we couldn’t figure it out, and it was time to rush the cart back into the reefer before they all broke.  But no, they all broke.

RJ told me this was how Dow Chemical started.  He must have meant BP, not Dal.  The stopper slips inside, for a hundred and five dollars.

1999

Scienceware Safe-Lab Stopper With Extracting Nut For Easy Stopper Removal; Standard Taper No.: 29/42

by Bel-Art

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Price: $105.30   Special Offers Available   o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o

In Stock. Ships from and sold by Fisher Scientific.

Only 1 left in stock–order soon.

2104

I’m short some words.  I don’t care.  It said 1999 and that’s what omma go by, what?  Right.  Let me put it in park and order soon.  I am short some customers.  I’ll make something and put it out there, no disparagement intended, Nintendo.  Very soon.  Quite soon.  Checkbook reading Billinghurst Laboratory, Stephen Billinghurst C.F.O., on my business card, a plastic one that’ll chop cocaine.  Resurrect my business license in San Diego, which sucks ass.

I detect a glitch.  I’m going to get a big space, fix that heading now.

A mortar crew has some of the best guys on it.  Good people, know what I mean?  Twelve thirty-four.  I’m going to get a call to go pick up the boy from the bus stop.  I shouldn’t eat Oxycocone past nine at night, and I shouldn’t eat it past eight.  The beers are sold so you become an alcoholic.  I started at a 12-oz a day.  You can’t buy a 12-oz.  The least you can buy is the amount that gives you a buzz.  I didn’t start out wanting a buzz.  I don’t drink and use drugs for that, and now it is influencing my son.  “You don’t want a buzz?”  No, and I want the head caved in on this big dude, that stinking fuck.  I do not actualy mind if every young man in America is sticking a needle in his arm.  All those guys on skateboards, bicycles, they look sharp.  C’mere take a second.  And the girls!  Little Christians, a product of the religion, have n—have never got drunk.  Passioned woman, give up your vows.

(*****) little lady in the City of Night.  Another lost angel, …

—The Doors

doing me a big favor

2390

No more pix. shot my wad, or I’d—(What would you do, daddy?).  Why if she were my daighter, I’d—

“What would you do, Daddy?”

Suzy Creamcheese, LA woman, ranch dressing, sadist

The flasseses, accords were reached, I had a five-L jacketed flask, and that had a flange.  I made it up to the flange, picking up the teflon gasket alone at a place near Biola College that sold process eqpt.  Even without it, we can go back to whoever is the rep for Schott Glass around here.  Nigger is out of bubble gum again.  They go out of biz with me as a customer.  Gus sold me a lot of my stuff out of a storage unit; he’s a PhD, the OC.  Not my LN2 dewar flask ( a metal can), on your desire to really condense vapors.  A lot of my stuff that the expert wit said did not go to make meth.  Could not get the last piece to put the rotovap together, or the vac train, or the hydrogen supply.  Your problem is the chem sources (title of a book with every mfg fool in industry worldwide), that is, no pont making it without all the chems, and no safety being in possession of said chems, aka ‘precursors’.

Don’t even “make”.  Just on that last post alone is a bunch of experiments.  Do those, and then don’t let the left hand know what the right hand is doing.  I know, it says the same thing in the Bible, the Good Book.  The Holy Scripture.  Hey, the Holy fuckin’ Bible, son.  Jay am owna set yo eye on faiah.

Title written by Geo. Harrison, Beatles.

2666

By exposing part of the winding coils and making the secondary connection through a sliding brush, an almost continuously variable turns ratio can be obtained, allowing for very smooth control of voltage. Applicable only for relatively low voltage designs, this device is known as a variable AC transformer, or commonly by the trade name of Variac.

From 1934 to 2002, Variac was a U.S. trademark of General Radio for a variable autotransformer intended to conveniently vary the output voltage for a steady AC input voltage. In 2004, Instrument Service Equipment applied and obtained the Variac trademark for the same type of product.

2765

125 grams per mole iodine, 22.4 liters per mole at STP, ideal gas.  Charging a flask with a pound of I2 is going to rapidly decompose into two-fers of HI(g), final product; 454.4 g, divided by musician (Creedence), by 125, 8 (look it up), TI-30X2s solar calculator, $15, 454.4/128 = 3.55 x 10 to the one, or 35.5.  What are these?  ten to the zero, or straight-up 3.55 moles, Homes.  A mole is a handful.  A pound, is that 35 handfuls fool.  3.55 x 22.4 = 79.52 L.  The closest flask size to that is the hundred-year sentence (little shed holds a pair) of 72-L flasks.  To make a pound?  3:1 molar ratio reagent to precursor implies about a pound, I mean a mole. a mole of E is not a pound; I believe that is 200 g per mole, ephedrine HCl.  every 200g going in makes 180g meth coming out, some of it dirty.  No, alike to a pound of iodine, as big as your fist (no put-y in pant-y, (ulceration, hospital stay)), made 80 L, 1000 cc per L, ten cm on a side is 1000 cc.  Oh, I don’t do the third root on this.  Guesses off 80,000, third root, trying, first the zeroes.  five.  At six, three, two.  0.8 x 100, times itself twice more, 80x80x80=500,000.  Trying 60 cubed, yielding 216,000, …yeah.  43 it is.  40% of a meter, 43%, times 39.37 m/in.   1.69 of a foot, 1.69 ft.  A cube that big on a side, knowing a 28.32 L/cu.ft., then yeah, Petco ballpark says.  Can you put a 2-ft. cube inside this flask, 8 cubic feet?  I didn’t think so.  My 72 must yield a few tens of pounds.  80′s what we have to take care of, so 3.785 L/ gallon, times INVERSE 79.52 L,Ls cancel, Equaline 47.6, …Invers wha? Was on backwards.  Per gallon, want gallons.  79.52 / 3.785 = 21, divide again by -never mind, four fives I can see that.  Four five-gallon water bottles hold 80 L.  A one-L flask connected on the push-pull to a gas train of 4 water jugs is sized out by us when a lb of the blue solid is all turned into the harsh gas.

3089

Next time, contg. P (pressure).  PV = nRT (ideal gas law)

3099

bes

No, no no no no.  Remember two-fers?

[Added later.]

I can think of three factors of two.  A pint, 473 mL, is considered a pound.   Water has a density of one.  With less than 4% difference between 454.4  and 473, a pint of liquid should weigh 473 g.  The density of HI, 57%, is 1.6.  1.6 x 473 = 756.8 g.  There’s about a pint of water there, but there’s also 756.8 – 473 = 283.8 g of the total 454.4 g of iodine, not counting the H of HI, which is 3.5 g, one gram per mole times the number of moles.  This leaves 283.8 – 3.5 = 280.3 g of iodine.  280.3/454.4 = 0.617 = 61.7 %.  100 – 61.7 = 38.3.  Theoretically, as much as this percentage of the volume is all that is in the gas phase, with the rest dissolved in the water.  But, we do not make 57% HI as a constant-boiling distillate.  We generate a reagent in situ.  We had iodine solid wth a volume of a few ounces turning into 38.3% of the volume 79.52  liters, or 30.456 L, of gas above the liqud.  But, it’s out of equilibrium, so it develops pressure and we don’t want to lose it.

We had offsetting mistakes, so the apparatus is of the size I described.  The first error is that the diatomic molecule I2 turns into two molecules of HI, so the volume would be 160 L, twice the 79.52.  The second error is that when you take the atomic weight of iodine off the chart at 128 g, it takes two, so that the molecular weight of molecular 

3333

Yeah, that’s bad English.

…iodine is 2×128=256 g/mol.  One pound is only 454.4 g/256 g/mol= 1.775 mol.  1.775 molx22.4 L/mol=39.76 L as an ideal gas.  We won’t get iodine vapor in this; we’ll get HI gas.  If you put iodine crystals with aluminum powder and put a drop of water on  it, it’ll turn out purple smoke, so that’s molecular iodine vapor.  I2 is more reduced than HI.  Althgough the I- anion is present, it’s the largest, while H+ is the smallest.  So, it’s a soft acid.  It’s closer to I+ and H- than HCl is to CL+ and H-.  The H- anion is called hydride, and a character like this is why only HI and no other halogen acid will do this rxn.  Lewis acid theory, Bronsted-Lowry theory, Arrhenius theory (1903).  I2 is not more reduced than HI.  It’s the other way around.  The I in HI has an oxidation state of -1.  The oxidation state of an element is always zero.

I think the HI gas should be trapped in a cold finger as the liquid.  Then you have to get this liquid to dissolve in water.  -35.4 C is the HI bp.  Acetone/dry ice is a -78 C cooling bath.  I’d prefer dry ice/isopropanol to dry ice/acetone.  They’re the same temp, and so is dry ice/ethanol.  Solubility

3546

obtaining  iodine crystals from tincture

drug enforcement version of same

3556

One more large database.  This makes two for this post, which is #628.

Electrochemistry Encyclopedia.  The first one was experiments, and, I might locate ANIMATIONS of phase diagrams; I’ve hit on oxidation state diagrams and oxidation number, but, I can’t find that  exact diagram for iodine.  Other short series are solvent polarity (search for a post), and the Electrochemical Series, which orders elements by their replacement of each other by the half-cell reaction.  another is electronegativity, but that is one of Pauling’s inventions.  It isn’t fundamental.  It’s akin to properties.  See of it a  couple of posts back.  That is, we surmise that we can think of unlimited new things to measure, but being chemistry, the number of these things itself approaches a minimum, and that is how everything on the chart is all there is.

Electrosynthesis

The push-pull (usually used for refrigerant recovery in the HVAC dodge) we’re talking about up in  here above, by UF.

3712

Recipe #6: Methamphetamine Via Tosyl Chloride Reagent

Toluene sulfonyl chloride, or, Tosyl chloride, for short, which is abbreviated in structures as ‘-OTs’ once it is reacted, is considered a “protecting group”.  We would not use it because of bringing all the ingredients together once, pulling a cook, isolating the product, and skeedaddling with the goods.  If you use this, you can’t do that.

4-toluenesulfonyl chloride

I don’t know if you can use it.  However, the Merck Index has weighed in on the issue and has basically stated, “Yes, you can,” by publishing the method starting from phenylalanine I have called, “Recipe #3″.

PA, ephedrine or pseudoephedrine, or even a hypothetical side chain completely formed, differ from phenyl-2-propanone in that the stereochemistry can be specified in the starting material.  Methamphetamine has stereochemistry, and, only one isomer gets you high.  The option of when you incorporate it determines the strength of the product.  That is, if you opt not to separate isomers and wind up with racemic product, it will not be as strong and will be a reason that the method is not a first choice.

That being said, making dope calls for the kind of luck that maybe a good snake charmer has.  You have to flow with the rattlesnake.  As such, the purchase of a nice speed, which, ephedrine itself is already speedy, and, it is very clean, has become a giant risk, and, requires a team effort.  Teams don’t show me anything.  The total overall risk and cost in a heavy law-enforcement environment may make this synthesis the right choice.

It is not even really one synthesis.  MDMA via tosyl chloride intermediate, and Methyl Grignard Addition to Phenylacetaldehyde Methylimine,

They show!  They show more than we all know!  Excuse me, I am rocking out.  It’s a Journey song, where the singer goes, “He knew!  He knew more than me or you!  It was totally something new!”  So stupid, rhyming ‘knew’ with ‘new’.

These highly valuable historical internet discussions are located, I believe, on the same database, and are a kind of archive material.  But, the discussions are often one-sided on the internet.  You need a little perspective, and that can easily be provided by reading a new book.  Although the term, ‘state-of-the-art’ is popularized for the purpose of shifting a sucker-fish’s attention towards the avarice of having a shiny new machine, the original phrase is ‘well-versed in the art’.  A chemist working as a chemist is assumed to be up to speed, or, he is going to be repeating the work of others.

My chemist is just Hudlicky, student of my first synthesis professor, Wenkert.  And, there is a lot of enjoyment to be derived from a Wenkert.  He’s just not a world figure, like Pauling, or the top number one ball-buster freak from Harvard dominating the field for thirty-forty years, occupying a whole wing of a chemistry building, and leading an entourage of fifteen students long after they have degrees.  That’s Corey.

But, anyway, we are not all beholden to a brave new world where chemistry takes over and there is a place in it for everyone.  Let’s face it, these are the tools.  You do not want to be relegated to hanging out with these guys.

Among the desired promulgations worming chemistry further into our lives, upsetting governments, creating dependence, propping up governments, gassing Jews, destroying the air, water, and ozone layer, there is ever so much more scapegoating as things go wrong.  For that we have the poorer “classes” of people, especially funky in the Bhopal “disaster”.  My book on that is Five Past Midnight in Bhopal, but, I am getting off-track.  The section on ‘Protecting Groups’ is in Hudlicky, The Way of Synthesis, pg. ____.  But, whatever & wait:  There’s a book he recommends called Protecting Groups.

I don’t know if we should ignore what Hudlicky himself says and go right to that source constituting a whole book.  It is best to be warned off from a bad idea.  The bad idea with protecting groups is you have to react your starting material with the protecting reagent, which is a large molecule, then isolate an amount of substance, then throw half that weight away when you decompose the adduct and isolate the product, even if you did get a high-percentage yield.

That and some other things, like, how dangerous are the by-products unique to this procedure?

Of course, any method for XTC is simply made easier if used to make meth.  But, here, you have to realize, chemistry professors have a different motivation for trying something than the public has a deep need to be experimented upon.  So, chemists and their ilk tend to invent diseases they may one day cure.  The scientists are much better at the intensive (meaning internal) collusion promoting science and elitism, and modern armies win in conflicts with savages, so, the right-thinking and good people have been overwhelmed by evil and predatory movements to enslave and liquidate them.  Like, I am saying, ‘This is how you make meth.  Am I wrong?’  But, ask society about that, and they will be pissed off.  The chemistry establishment is consisting in a great unacknowledged and ulterior motive.  The only thing that makes a new procedure worthwhile is if it makes better speed!  So, since we are making better speed, not curing cancer, reading between the lines of a discussion on what is an ‘advantage’, like a cost advantage or an ease advantage, we spin into a nude sunrise – - – I mean, wait.  Okay.  The ‘novelty’ of a procedure is enough to get a PhD.  It has to be new.  That’s enough for science.  Even past that, when it is enough to address what society wants, scientists in the labs have never worked for society.  They have either made better reductive aminations or we took them for a ride.

I am getting a touch of conspiracy paranoia, so, I will stop.  A guy shot two Pentagon guards, and I guess he had fallen into that internet trap which creates new wackos all the time.  Here’s your starting material now, but get a clean product racemate.  The users can’t protect themselves.  I’d say do a column chromatography cleanup until DEA weighs in on the horrors of the by-products.

Phenylacetaldehyde.

You don’t go shopping around for different replacements of the tosyl chloride, since it is fed in here because of it being a chemical by-product of another process, making it cheap.  Somebody said $23/kg, but, I don’t know when they said that.  Keep an eye on the molecular weights.  Chemistry only works on moles, and they translate into widely differing masses.

My reasoning process started with Recipe #3, which has two protecting groups.  If the amine is already present in the molecule, establishing that you are going to target (+)- methamphetamine, that has to be protected with -BOC, or you will get the tosylate of that as well as of the other functionality, like the -OH of -COOH.  This procedure is trick because. depending on how you deprotect, you can get either amphetamine or methamphetamine.  They call that a procedure with “general utility”.

But, -OTs is a leaving group in an SN2 substitution reaction.  I have to see if that means a reversal of stereochemistry (later I’ll do that).

Really terrible leaving groups require extreme conditions, but, this chloride is already a nasty substance, and the methanesulfonyl chloride, likewise.  They did not mean that.  They only mean the electronic favorablity of a reaction makes it easy, not that you are going to stand over a bottle while you open it.  They assume you have a fume hood.  If you do, who breathes the air where it exhausts, a bunch of snitches?  You pull the sash down and get a good face velocity, so, a scrap of paper shoots right past you and up the duct.

The methyl magnesium grignard

H3CMgI

methyl magnesium iodide.  This has to be prepared.  So, I think these four things and their solvent requirements will make a batch of meth:

1. phenylacetaldehyde

2. methylamine

3. tosyl chloride

4. methylmagnesium iodide (in ether)

I do not think I am all right.  I lost some details.  I bet my eyes look confused.  That’s a bad sign.  I am about to be cruel to someone.  Hey, I don’t talk except to scream.

No, I guess it is 1 &4, making phenyl-2-propanol, then tosylation.  Then methylamine to give methamphetamine.

Now, where do you separate isomers, and, where is the one where you add TsCl to phenylacetaldehyde?

Acta Cumbactadis

1407

Phenylalanine Rhodium

[www.rhodium.ws] / [Chemistry Archive]

Synthesis of Dextroamphetamine Sulfate and Methamphetamine Hydrochloride from D-Phenylalanine

David B. Repke
Journal of Pharmaceutical Sciences Vol. 67, No. 8, pp 1167-1168 (1978)

Abstract

Starting from D-phenylalanine, dextroamphetamine sulfate and methamphetamine hydrochloride were synthesized. The reaction sequence proceeds through three intermediates, in which the absolute configuration of the asymmetric carbon atom is changed but the relative configuration remains the same. Either product can be obtained from a common intermediate by altering the reductive conditions employed for the removal of a carbamate protecting group. Following initial observations on the sympathomimetic properties of amphetamine and related compounds^1-4, the racemate of amphetamine was introduced into clinical medicine for the relief of nasal congestion⁵. The (S)-(+)-isomers of amphetamine [dextroamphetamine (V)] and methamphetamine (VI) (Scheme I) have been used in the therapy of obesity, narcolepsy, parkinsonism, and certain behavioral disorders⁶. Considerable interest also has been generated in the central stimulant properties of these compounds⁷.

dl-α-Methylphenethylamine and D-α,N-dimethyl-phenethylamine have been prepared by several routes^4,8-12. The deuterium-labeled analogs of these compounds also have been synthesized^13,14. Karrer and Ehrhardt¹⁵ originally prepared V from D-phenylalanine via the N,O-di-p-toluenesulfonate derivative of II. Using a modification of that procedure, Gal¹⁶ recently synthesized the deuterium analog of V and the corresponding (R)-(-)-isomer for use as internal standards in GLC-mass spectral studies. An asymmetric synthesis of V also was described¹⁷.

An earlier report¹⁸ presented the synthesis of (R)-(-)-and (S)-(+)-α-methyltryptamine from the corresponding tryptophan isomers. The present work outlines the application of this method to another aromatic alpha-amino acid, phenylalanine.

The reaction sequence (Scheme I) is essentially the same as that used previously¹⁸. In contrast to the corresponding indole analog, the N-benzyloxycarbonyl-O-p-toluenesulfonyl intermediate (IV) is a stable, crystalline solid. The substitution of nitrogen with a carbamate group has the advantage of providing either the primary (V) or secondary (VI) amine, depending on the conditions employed for the reduction of IV. Although the preparation of N-methylamino acids by lithium aluminum hydride reduction of their N-benzyloxycarbonyl derivatives has been known for years¹⁹, this reaction has seldom been applied to other types of amines²⁰.

Experimental

(R)-(+)-2-Amino-3-phenylpropanol (II)

To a suspension of 1.3g (34 mmoles) of lithium aluminum hydride in 75 ml of anhydrous tetrahydrofuran was added, in portions, 2.1 g (12.7 mmoles) of D-phenylalanine. After the addition, the reaction mixture was refluxed for 20 min and cooled to room temperature. Then the complex and excess reagent were decomposed by dropwise addition of 2N aqueous sodium hydroxide and water. The white solids were collected by filtration and washed with 100 ml of tetrahydrofuran.

The filtrate and washings were combined and concentrated under reduced pressure. The residual clear oil slowly crystallized and was recrystallized from ethyl acetate-hexane, 1.75 g (91%), mp 90-91° [lit.²¹ mp 91-92°], [α]D 23.8° (c 1.0, ethanol) [lit.¹⁹ [α]D 24.6°].

(R)-(+)-N-(Benzyloxycarbonyl)-2-amino-3-phenylpropanol (III)

A mixture, of 1.5 g (9.9 mmoles) of II and 1.12 g (10.6 mmoles) of sodium carbonate in 25 ml of acetone and 25 ml of water was stirred at room temperature, and 1.5 ml (10.5 mmoles) of benzyl chloroformate was added. The reaction mixture was stirred for 3.0 hr, diluted with 50 ml of water, and acidified (to pH 2) with concentrated hydrochloric acid. The mixture was shaken with 300 ml of ethyl acetate, and the organic phase was washed with 100 ml of saturated aqueous sodium chloride. After drying (magnesium sulfate), the filtered organic solution was concentrated in vacuo. The product was crystallized from ethyl acetate-hexane, 1.5 g (55%), mp 91-92°C, [α]D 41.3° (c 1.0, ethanol).

(R)-(+)-N-(Benzyloxycarbonyl)-2-amino-3-phenylpropanol p-Toluenesulfonate (IV)

Compound III (1.25 g, 4.4 mmoles) and p-toluenesulfonyl chloride (955 mg, 5 mmoles) were dissolved in 100 ml of pyridine The solution was stored at room temperature with the exclusion of moisture for 4 days. Water (2.0 ml) was added; after 30 min, the solvent was distilled under reduced pressure. The residue was partitioned between 300 ml of ethyl acetate and 75 ml of saturated aqueous sodium bicarbonate, and the organic phase was dried (magnesium sulfate). After filtration of the drying agent and concentration of the filtrate, the residual semisolid was preparatively chromatographed on two 1-m x 20-cm glass plates coat with 750-um layers of silica gel GF, using 5% acetone in benzene as the developing solvent. The product band was removed from the plates and eluted with ethyl acetate. Concentration of the eluate afforded a clear syrup, which was crystallized from ethyl acetate-hexane, 985 mg (50%), mp 96-97°C, [α]D 29.7° (c 1.0, ethanol).

Dextroamphetamine [(S)-(+)-α-Methylphenethylamine] (V) Sulfate

Compound IV (250 mg, 0.568 mmole) and 100 mg of 10% Pd/C were mixed in 30 ml of absolute ethanol, and the reaction was shaken under 50 psi of hydrogen for 1.0 hr. The catalyst was removed by filtration (celite), and the filtrate was concentrated in vacuo. The residue was partitioned between 30 ml of 1N aqueous sodium hydroxide and 200 ml of ethyl acetate. The organic solution was washed with 50ml of water.

The dried (magnesium sulfate) solution was concentrated under reduced pressure (bath temperature of 25°C), and the oily residue was distilled in vacuo (Kugelrohr apparatus) at 0.05 mm and 40-60°. The clear distillate was dissolved in 3.0 ml of ether and carefully acidified (to pH 4) by addition of 0.2N H2SO4 in ethanol. The white solid was collected by filtration, washed with ether, and dried in vacuo to give 40 mg (38%), mp >300°, [α]D 20.1° (c 1.0, water) [lit.²² [α]D 21.5°]. The IR spectrum was identical to that reported for this compound²³.

Methamphetamine [(S)-(+)-α,N-Dimethylphenethylamine] (VI) Hydrochloride.

To a stirred suspension of 200 mg (5.26 mmol of lithium aluminum hydride in 5.0 ml of tetrahydrofuran was added a solution of 250 mg (0.568 mmole) of IV in 5.0 ml of tetrahydrofuran, the reaction mixture was refluxed for 30 min and cooled to room temperature and the complex was decomposed by careful addition of 2 N aqueous sodium hydroxide and water. After filtration of the white solids the filtrate was concentrated in vacuo. The residual oil was distilled in vacuo (Kugelrohr apparatus) at (0.05 mmHg and 40-60°C. The distillate was dissolved in 2.0 ml of ether, and the solution was acidified by addition of saturated hydrogen chloride in ether. The crystalline plates were collected by filtration, washed with ether, and dried in vacuo, yielding 65 mg (62%), mp 171-173°C [lit.⁹ mp 172°C, [α]D 15.1° (c 1.0, water) [lit.²⁴ [α]D 14-20°]. The IR spectrum was the same as that reported for this compound²³.

References

1. G. Piness, H. Miller, and G. A. Alles, J. Am. Med. Assoc., 94, 790 (1930).
2. G. A. Alles, J. Pharmacol., 47,339 (1933).
3. G. A. Alles and M. Prinzmetal, ibid., 48,161 (1933).
4. W. H. Hartung and J. C. Munch, J. Am. Chem. Soc., 53, 3, (1931).
5. C. D. Leake, “The Amphetamines, Their Actions and Uses” Charles C Thomas, Springfield, Ill., 1958.
6. “The Pharmacological Basis of Therapeutics,” 5th ed. Goodman and Gilman, Macmillan, New York, 1975
7. Weiss and V. G. Laties, Pharmacol. Rev., 14,1 (1962)
8. G. Edeleano, Chem. Ber., 20,616 (1887).
9. H. Emde, Helv. Chim. Acta, 12, 365 (1929).
10. G. A. Alles, J. Am. Chem. Soc., 54,271 (1932).
11. O. Y. Magidson and G. A. Garkusha, J. Gen. Chem., (USSR) 339 (1941); Chem. Abs., 35, 5868.
12. A. Larizza, G: Brancaccio, and A. Segre, J. Med. Chem 9, 996 (1966)
13. B. Lindeke and A. K. Cho, Acta Pharm. Suec 9, 363 (1972)
14. A. F. Fentiman; Jr., and R. L. Foltz, J. Labelled Compd. Radiopharm. 12, 69 (1976).
15. Karrer and K. Ehrhardt, Helv Chim Acta, 34 2202 (1951)
16. J: Gal, J. Labelled Compd. Radiopharm. 13, 3 (1977)
17. D. E: Nichols, CP. Barfknecht, D. B Rusterholz, J. Med. Chem. 16, 480 (1973).
18. D. B. Repke and W. J. Ferguson, J. Heterocycl Chem. 13, 775 (1976)
19. P. Karrer and B. J. R. Nicolaus, Helv. Chim. Acta 35, 1581 (1952)
20. H. E. Smith, E. P. Burrows, and F. M. Chen, J. Org. Chem. 1562 (1975).
21. J. B. Jones, D. W. Sneddon, and A. J. Lewis, Biochim.Biopharm. Acta, 341, 284 (1974).
22. J. Cymerman Craig, R. P. K. Chan, and S. K. Roy, Tetrahedron 23, 3573 (1967).
23. E. C. G. Clarke and J. Berle, “Isolation and Identification of Drugs,” Pharmaceutical Press, London, England, 1969.
24. “The Merck Index,” 8th ed., Merck & Co., Rahway, N.J., p. 332.

Methamphetamine Via Phenylalanine

This is “Hydride” on Wikipedia.  I was Googling, “Selective Hydride Reducing Agents”, and hoping that the reference section on the Wiki article would contain it.  This title (in quotes), is what would be called a “leading reference”, if that exists.  I need to call up my local Science Reference Librarian and ask where the free resource for locating citations is.  The subject was explored at a certain time in chemistry history.  You don’t go back to that time in history.  You trace the development since then by anyone who has improved upon it.  That’s usually Science Citation Index, but this is the internet age.

The entry in the Merck Index on Methamphetamine contains a reference to its synthesis using phenylalanine.  That’s what I call Recipe #3, but, I see from a quick search of this blog that I quit before making it accessible.

I am not exactly like Uncle Fester.  The differences are that he can control other websites, while I am not about to use the “SWIM” anti-bust technology or be cursed and banned from forums.  And, he believes in accommodating the law to have ways to manufacture.  I believe that the laws are not designed to keep dope from being made, sold, or used.  They are there to force the dope to be made in ever-larger quantities to increase our enslavement, exploitation, and our powerlessness to turn a corrupt society around.  It is just being made in other countries, using methods which lend themselves to organized crime.  Phenylalanine is one of these, because Nutra-Sweet is made from phenylalanine.

I am in agreement with Fester that the chemistry of yields from alternative sources of the carbon fragments due stereochemistry, and the various reagents’ effects on yield are important.  I also like laboratory improvements, called “Good Laboratory Practice (GLP cf Good Manufacturing Practice, GMP)”, on the recycling reagents aspect, or the use of minimal solvents, other “green” considerations, as well as the respect for property.  I do not respect large Nutra-Sweet plants in South America being turned into meth factories and think they should be bombed.

I don’t even have the Merck index article here.  I thought I did.  So, this is a quick post such that I can at least retrieve it on a search.  Fester posts it as,

quote

Rough times are causes for digging. Showing ID for sudafed is BS and all my neighbors are pissed off at the high prices they pay to get the pharmacist to wait on them for a box of sudafed. There should be several clandestine routes to a amphetamine…or better dexedrine..like electric reduction of the acid to the aldehyde and then zinc plus HCl to reduce the aldehyde to amphetamine…and there would be other ones..the problem is looking at J. Pharm. Sci. Vol.67 (1979)..it seems that the unnatural isomer…D-phenylalanine..will reduce to dex. The article says that the absolute configuration of the atom (attached to the amine) is changed by their procedure, but the relative configuration stays the same. I see the drawings, and it doesn’t look good for natural L-phenylalanine..but has anyone tried some reduction methods beside LAH?

unquote

That’s from one of the websites he recommends in his new book.  It is called, ‘Wetdreams’.  Then, I wasn’t going to get into a big discussion with him, but I was in my car, about to get a DUI, and it wouldn’t leave me alone.  You know, someone is on your mind, and no matter what you think, there’s another point of view, presumably their point of view.

See, I already don’t like Owsley Stanley.  Let’s face it.  Truthfully, ever since 1979-80, when America was about to be enamored and hammered by a love affair with cocaine, one Richard C. Hall was in the Midwest, in Columbus Ohio, and he was big in clandestine chemistry, and he got killed.

Now, I know John Cougar Mellencamp is a Midwest champion, and a “dreamer” is a clandestine chemist, so, here’s what he writes:

quote

Used to daydream in that small town
Another born romantic that’s me

But I’ve seen it all in a small town
Had myself a ball in a small town

unquote

It is another clue, so, I enter the text as the clues.  The dope mfg. enterprise has a demonic and extrasensory aspect to it, and I must give the devil his due.  It’s part of my history.  I don’t start when they start.  I start ‘em where I find ‘em.  It is a bit like having a kid.  You start them, but get married first.

No, I like Bruce Springsteen.  He’s not a bully, or a stupidhead, Nicholas.  He’s a Deadhead.  He’d be playing right alongside Jerry Garcia, onstage.  That’d be boss.

quote

Last night me and Kate we laid in bed
talking about getting out
Packing up our bags maybe heading south
I’m thirty-five we got a boy of our own now
Last night I sat him up behind the wheel and said son take a good look around
This is your hometown

unquote

Now we have touched on the South, the Northeast, and the Midwest.  Hell, that’s all of America.  Green Bay has a football team!  I didn’t know small hometowns had NFL teams.

858

Sherri Strange, Head of DEA Atlanta, seen in a 2006 video on meth, which also has a slide show of meth images which are positively pornographic.  The so-called “normal” or “upstanding”, “right”, segment of society frequently is responsible for the unwitting glorification of drugs and drug use. Even if I need drugs, I hardly want pictures of it.  These pictures make me want to go out and find the drugs.  Even the drugs make me choose a path in life I would not otherwise pick.  I’m not too stupid, I am far gone insane.  What I say is not take-it-or-leave-it.  I don’t even know if SS is still the one in charge.  As head of DEA Atlanta, she is something.  Once she leaves, her opinion means nuts.

Thanks go to whoever asks what the definition of a “three way script” is.  It is a movie script involving three characters, probably two men and a woman.  One man is the fool, spending his money on a woman who is having sex with another man.  That’s why I like prison.  You will be wooed.  I will fuck you face-to-face family style, throwing your legs up over your head.  I like them with a little blond mustasche.  We should have a love tryst.

1073

My ’858′ I left there as the post got edited.  That could be BSB, and I am, so, I left it like it was.  I added six words.

Like trying to ignore Mr. Fester and having his persona shift from a website to my car radio, which places me ‘reactive’, the ESP is always reactive.  Proactive is when you get up and want to write.  I do not do that.  If I had an office I would not work there.  I went to college and all desire to study left me.  The last time before this I saw ESP, I had two vehicles in front of me, but one had a deadhead flag (made up by Owsley), and the other one had the “EAD” of DEADHEAD in it.  I knew that this could not be the ‘single force’ conspiracy of human intervention, so it is ESP.  All strange ESP-style psychic events lose their impact, i.  They require the participation of a single observer, ii. The results require multiple lines of evidence converging, and the documentation is missing some of them.  It must be even stranger than it seems.  It comes and goes without leaving a trace.

quote

One thing for certain it ain’t never gonna stop
When it all gets too heavy
That’s when they come and they go

…

When the street lights flicker bringing on the night
Well they’ll be slipping into darkness slipping out of sight
All through the midnight
Watch ‘em come and watch ‘em go
With only one thing in common
They got the fire down below.

unquote

See, that’s Bob Seger, another Midwest boy.  He makes it like it is sex, but that does leave a trace—all us.  He’s in a movie, Mask, as his songs, in a movie with biker meth.

quote

1373

Posted Thursday March 12, 2009

From WWD Issue 03/12/2009
LOS ANGELES Charles Mask Lewis, co-founder of the mixed martial arts clothing company Tapout, died in a car crash early Wednesday morning.

According to the Newport Beach Police Dept., Lewis was driving a red Ferrari that spun out of control along with a white Porsche on a quiet stretch of the beachside community around 1 a.m. Lewis car struck a curb and then a light pole. He was pronounced dead at the scene.

A female occupant who was ejected from the Ferrari was later transported to a hospital, where she is currently in stable condition. Police didnt confirm the womans identity.

Officials said the driver of the Porsche was Jeffrey Kirby, a 51-year-old resident of Costa Mesa, Calif. After fleeing the scene, Kirby and a female passenger in the Porsche were found a short distance away. Kirby was arrested for gross vehicular manslaughter while intoxicated. The unidentified female passenger was arrested for public intoxication and later released from custody.

1537

unquote

I hope you didn’t have somewhere to be; don’t go trying to make up time on the road.  I ruin my posts.  Oh, I forgot Haiti.

A nigger with no food won’t fart.

On Bob Seger, I am sure the various parts of the Midwest have their own pride, like if you was near a giant fresh-water lake.  Are they?  Anyway, the Bay City Rollers, a band, was named because a dart thrown at a map hit Bay City, Michigan.  And I was in Bay City, Michigan.  and, Bob Seger and the Silver Bullet Band were in Bay City that night.  I did not go.  Then, Adam Sandler’s line in Reign Over Me, is, “You’d get your ass kicked at a Seger concert.”  No.  A Rock-n-Roll concert is a ripoff. What is “getting laid”?  Isn’t that what 1,000 troops do when they hit town?  Do you want them dying at war without tasting of at least a bong hit?  The Who song is not even “Reign Over Me”.

Oh.  It’s “o’er”.   I didn’t know that.  That’s not ‘over’.  It’s the Who, and I am not a fan.  I’m a Beatles fan.  No.  I am not a fan because I don’t go to see phonies.

quote

Only love
Can make it rain
The way the beach is kissed by the sea.
Only love
Can make it rain
Like the sweat of lovers’
Laying in the fields.

Love, Reign o’er me.
Love, Reign o’er me, rain on me.

Only love
Can bring the rain
That makes you yearn to the sky.
Only love
Can bring the rain
That falls like tears from on high.

unquote

It is going to rain here pretty soon for six days; a soft rain in San Diego.  That’s the forecast, but, the news can slant it whichever way they feel like.  Maybe right now they want us to worry about extreme weather.  I will bet you it isn’t any six-days-of-rain.  It hasn’t even really started (Monday, 1:17 PM).

That’s from Quadrophenia.  We had quadrophonic stereos going on sale at the time.  My old friend Jeff Irvine said “It won’t work.  You only have two ears.”

Like watching ventriloquism on TV.  How can you hear him throw his voice?  I like hand grenades.  Nobody acts like the explosion is coming from somewhere else.  I think I saw a suicide bomber yesterday.  He looked like a terrorist, you know.  He was on his way somewhere else.  I said, “Bro, you have reached the marketplace.  This is a target-rich environment.  Let me just gather up my stuff and get on out of here.”

1969

“Start getting ready, Stephen.”

1973

Otto Snow Patent 2002 Amphetamine Syntheses Industrial

Here it is here. I did not like the legibility of the HTML version.  Please click the link and d/l the PDF.

otto snow pdf amph synth

Plus, then I uploaded ‘media’ and put a nother one of the same file there.

To Upload a Clan Lab How-to PDF

The Construction & Operation Of Clandestine Drug Laboratories (2nd Edition Revised & Expanded) By Jack B Nimble l

. Here’s where I got how to do it from. I made it so you have to click the period at the beginning of this sentence. It’s not even that good. It doesn’t say to entitle your post before uploading. I think it is always good to start with a title, because it autosaves a draft when you tab to the body.

79

I’m seeing if it works. If there are no more words, that means it worked. I didn’t even want to do this. this is a test of another AT&T ISP at “my wife’s house”, she just got. I am depressed because I’m a terrible writer when I’m writing, and good later, when I’m thinking. All the icicles, the icicles are falling. I just wrote down what came over the television. all this stuff they put on commercials and shows is obviously written by writers better than I. Just do what I tell you to do. Don’t worry about how it’s written. It’s depressing. We’re not making any innovative laboratory designs. Just trying not to be detected.

195

I turned around to post the file size, click on tags and categories. It took a few minutes to move over for me when I clicked the link “the construction …” above. I have a fast connection, so don’t click it if you don’t have several minutes to wait. Oh. I didn’t even want to look at it, but I noticed at the end it says spot remover’s dichloromethane. Nah. How many times have I said it, spot remover’s the related compound, carbon tetrachloride. DCM’s CH2Cl2, chloroform’s CHCl3, and carbon tet’s CCl4. The difference is that there’s an overpopulation problem in this world and science and industry is well-served by immersing you in more toxic compounds, and that would be CCl4. So, as you can see, if you believe that spot remover is CH2Cl2 and it’s really CCl4, you’ll kill yourself. They have characteristic smells, BTW. The ingredients as listed on the labels of many products may say petroleum distillates. What the hell is that? To do the identical obfuscation here, they should call them chlorinated hydrocarbons, a catch-all phrase. I’d go to Stepan, Rohm & Hass, Tergitol, and get on them as follows: “Hey, this raw material you sell. I want to use that. Can you give me a starting formulation using that so that I may make a product out of it?” They usually do. Dow, duPont. You have to find out some other way what they make. They make so many that they might not want to tell you everything they make. The file size is 6.94 MB.

454

Spot Cleaning Fluids

Screen Print Ink Cleaning Fluids
Superkleen® S.P.I.F® S.P.I.F.® II Expert Scorch Remover
Spot Cleaning Fluids

During the screen printing process, ink smudges caused by fingerprints or marks on the screen can be a costly problem. S.P.I.F. ink removers, applied with an Albatross Spot Cleaning Gun, eradicate these marks quickly and completely, allowing the garment to be sold as first quality.

Superkleen S.P.I.F. and S.P.I.F. II offer the high solvencies and fast evaporation rates necessary for efficient ink removal. They both remove cured plastisol, oil and water-based ink from all textiles. They are both manufactured exclusively with highly refined virgin solvents to insure crystal clear color. This eliminates the risk of a chemical “ring” being left on the cleaned fabric.
Superkleen® S.P.I.F®

SPIF Spot Remover

MSDS Need a Spot Cleaning Gun? Superkleen SPIF Spot Cleaning Fluid

Superkleen S.P.I.F. completely removes cured plastisol inks, most water-based inks, flock lettering and adhesives from all textiles. It’s unique oxygenated formula leaves fabric free of any trace of the ink smudge. Unlike other cured ink removers, S.P.I.F. is a full strength product and does not contain any petroleum hydrocarbon “fillers.” This insures that the ink marks are removed using a minimum of product.

Superkleen S.P.I.F. does not contain 1,1,1 trichloroethane, dichloroflouroethane or any ozone depleting substances. It is exempt from SCAQMD’s rules #1171 and 1130.1. It has no flashpoint up to the boiling point. Superkleen S.P.I.F. contains methylene chloride (also known as dichloromethane) and must be used in compliance with OSHA’s exposure standards. Effective on April 10, 1987, OSHA’s threshold limit value (TLV) on methylene chloride was set at 25 ppm, with a short term exposure limit (STEL) of 125 ppm.
Part Product Size Case Qty

List Price
Price Case Price Each
591075

Superkleen S.P.I.F.

Cured Ink Remover
Gallon 4 $39.62 $37.64 $35.66
591077 5-Gallon N/A $184.70 $175.47 N/A

746

“Carbona Not Glue”, lyrics by the Ramones (like saying you should do something more poisonous):

Wondering what I’m doing tonight
I’ve been in the closet and feel all right
Ran out of Carbona, Mom threw out the glue
Ran out of paint and roach spray too

It’s TV’s fault why I am this way
Mom and pop wanna put me away
From the early morning movie to the late late show
After it’s over nowhere to go

And I’m not sorry for the things I do
My brain is stuck from shooting glue
I’m not sorry for the things I do
Carbona not glue

850

It’s killed so many people by now you can’t just turn it up. Why am I doing this again? And why did I let my estranged wife take my car? Oh. I guess ’cause she’s letting me use the internet. I just end up with a long post that doesn’t say anything. Fuck it. Here’s a long list of chemicals used by vintage sewing afficionados:

soap
water
lemon juice
ammonia
gasoline
kerosene
turpentine
a tampon
whiting
French chalk
chalk
vinegar
warm water
thick paste of raw starch and water, let dry, brush off (Oh. That’s for blood. make a note.)
a sponge
bluing is a stain
wax is a stain
Javelle water (explained somewhere. I can tell you: a solution of anything is not a pure compound, and you should not pay for solutions)

candle wax and grease-stains. Use blotting paper and warm iron. Move the blotting paper around. If the wax is colored, use a sponge with alcohol to remove the color.

borax
cold water
coffee—stain. Use boiling water from a kettle. Hold it high enough so the water hits the fabric with force, held over a bowl.

soak, expose to the sun, repeat; for dye—a stain

That Javelle water must really be something. It says, “as a last resort”

lard, for fly paper? What if a kid gets all wrapped up in it? Oh, yeah. That makes sense. It’s only lard. When do you get to douche a kid in Carbona? That’s what I want to know. Let’s try chewing gum.

Naw. They got gum/gasoline or lard, and then fabric. I want gum/xxxx/kid. You cut their hair out, let’s face it. Let me place the straight scoop about this material online. I mean it’s good. It’ll make you meet God sooner. Hell, I know some things that’ll melt a DEA man’s badge down, like ODCB, for starters. “Ortho dichloro benzene”. That’s a funk so rough it makes Agent Orange look like candy—washable. Each of you get a wash bottle and take three paces, turn and fire. Done deal. If you get splashed, you might make it to the rest room. Then again, you might not. Nah, it isn’t that bad. It’s a 3, sure, out of 20. Putrescine and cadaverine, chloroacetone, butyric acid, …

oxalic acid (I’m back to innocent stuff. This isn’t innocent. Don’t assign an infant to making up a dilute enough solution from the pure crystals). One of these things is sulfuric acid in powdered form. One of them is going to make a gas when you rub two solids together. But, either it makes holes or it takes out the stain. Finesse it.
ink—a stain. Paste of dry mustard and water.

salts of lemon juice. What the hell is that? How about just lemon juice. It sounds like eye of newt.
javelin water
chloride of lime
“follow the directions on the box”

What!!? Oh, hell no. Hey. Chloride of lime is not related to salts of lemon, just a word to the wise. We got a price up there? Let me put this carbon tet blurb down, and then, …

Carbon Tetrachloride

Description:

Carbon tetrachloride (C.A.S. 56-23-5) is a clear, heavy liquid with a strong, aromatic odor. It is not believed to occur naturally, but is produced in large quantities for use in the manufacturing of refrigerants and propellants for aerosol cans. It is also used as a feedstock in the synthesis of chlorofluorocarbons and other chemicals, in petroleum refining, pharmaceutical manufacturing, and general solvent use. Until the mid 1960s, it was also widely used as a cleaning fluid, both in industry, where it served as a degreasing agent, and in the home, where it was used as a spot remover and in fire extinguishers.

Chemical properties:

Carbon tetrachloride is a highly volatile liquid with a strong etherial odor similar to chloroform. It mixes sparingly with water and is not flammable. When heated to decomposition, it emits highly toxic fumes of phosgene and hydrogen chloride. There is strong evidence that the toxicity of carbon tetrachloride is dramatically increased by its interaction with alcohols, ketones, and a range of other chemicals.

Carbon tetrachloride is known to deplete the ozone layer, where it is responsible for 17 percent of the ozone-destroying chlorine now in the stratosphere due to human activities. Carbon tetrachloride has a half-life of between 30 and 100 years.

Synonyms for carbon tetrachloride are carbona; carbon chloride; carbon tet; methane tetrachloride; methane, tetrachloro-; perchloromethane; and tetrachloromethane.

unquote

Yeah, that’d be funny: “Doc, I got a blurb here under my skin over the ribcage.”

Yeah. “Maybe it’ll go away”. Then again, maybe it wouldn’t have popped up if it wasn’t going to get bigger. I saw a guy yesterday with a lump on his face. You can shoot up a lot of places, but not right on the side of your face. Put a steel stud there.

1654

I got to be off the computer when shorty walks in. She said.
peroxide
permanganate crystals in water (Don’t get me started on that.)

Any (d) Carbon tetrachloride or chloroform Sponge the stains or soak them. Paint stains that have become hardened are almost impossible to remove.

See what I did there? You’re fabric, if it isn’t obvious.
Plain, ordinary laundering. that’s all we ask, that you get a good night’s sleep before you come to work.

MIDLAND, Mich., Nov. 28 /PRNewswire/ — Dow Chemical U.S.A. has notified customers of a 1-1/2-cent per pound increase in the price of carbon tetrachloride, effective Jan. 1, 1985.

Under the new schedule, bulk quantities of technical grade carbon tetrachloride will be 25-1/2 cents per pound east of the Rocky Mountains and 26-1/2 cents per pound west of the Rockies.

Drum quantities will be priced at 32-1/2 cents per pound in the East and 33-1/2 cents per pound in the West.

1803

Chemical Identification
Carbon Tetrachloride, Reagent

Catalog # Formula F.W. CAS #
C1981 CCl4 F.W. 153.82 56-23-5

Synonyms: Tetrachloromethane

Chemical Pricing

Unit Size

Price

Quantity

Add to Cart

500 mL

$212.46

1 L

$313.70

No, no, no, no, no, no, no, no, no, … That should be a dollar a pint, 473 mL. No, no, no, no. That’s Advance Scientific and Chemical, online. Something’s wrong.

1857

Chemical Identification
Methylene Chloride, Technical

Catalog # Formula F.W. CAS #
M1252 CH2Cl2 F.W. 84.93 75-09-2

Synonyms: Dichloromethane; Methylene Chloride

Possible carcinogen.

Chemical Pricing

Unit Size

Price

Quantity

Add to Cart

500 mL

$29.60

It’s still fifteen times too much. I would always do it, if I wanted the drugs. Make it back on the other end. If you have the money in your pocket, it won’t hurt you to spend it. Go ahead. You can’t find out what it does if you can’t light it on fire. The torches they got these days, anything will burn. Nah, I’m kidding. Oh, you’re not kidding?

1955